2021 IEEE International Conference on Acoustics, Speech and Signal Processing

6-11 June 2021 • Toronto, Ontario, Canada

Extracting Knowledge from Information

2021 IEEE International Conference on Acoustics, Speech and Signal Processing

6-11 June 2021 • Toronto, Ontario, Canada

Extracting Knowledge from Information

Technical Program

Paper Detail

Paper IDBIO-8.6
Paper Title ACUTE LYMPHOBLASTIC LEUKEMIA DETECTION BASED ON ADAPTIVE UNSHARPENING AND DEEP LEARNING
Authors Angelo Genovese, Università degli Studi di Milano, Italy; Mahdi S. Hosseini, University of New Brunswick, Canada; Vincenzo Piuri, Università degli Studi di Milano, Italy; Konstantinos N. Plataniotis, University of Toronto, Canada; Fabio Scotti, Università degli Studi di Milano, Italy
SessionBIO-8: Biological Image Analysis
LocationGather.Town
Session Time:Wednesday, 09 June, 14:00 - 14:45
Presentation Time:Wednesday, 09 June, 14:00 - 14:45
Presentation Poster
Topic Biomedical Imaging and Signal Processing: [BIO-MIA] Medical image analysis
IEEE Xplore Open Preview  Click here to view in IEEE Xplore
Virtual Presentation  Click here to watch in the Virtual Conference
Abstract Computer Aided Diagnosis (CAD) systems are increasingly utilizing image analysis and Deep Learning (DL) techniques, due to their high accuracy in several medical imaging fields, including the detection of Acute Lymphoblastic (or Lymphocytic) Leukemia (ALL) from peripheral blood samples. However, no method in the literature has specifically analyzed the focus quality of ALL images or proposed a technique for sharpening the samples in an adaptive way for the purpose of classification. To address this issue, in this paper we propose the first machine learning-based approach able to enhance blood sample images by an adaptive unsharpening method. The method uses image processing techniques and DL to normalize the radius of the cell, estimate the focus quality, adaptively improve the sharpness of the images, and then perform the classification. We evaluated the methodology on a public database of ALL images, considering several state-of-the-art CNNs to perform the classification, with results showing the validity of the proposed approach. For a complete reproducibility of the work, the source code is available at: http://iebil.di.unimi.it/cnnALL/index.htm.